Anxiety

Symptoms of anxiety are increasingly prevalent during the menopause transition and are often associated with hot flashes. Anxiety can manifest as intense feelings of worry and fear, often along with physical symptoms like a rapid heart rate, sweating, and heavy breathing. But there’s good news... as hormones even out AFTER menopause, the increased anxiety can subside.

The science

Dr. Anna Barbieri, MD

Pro tip #1

The Mediterranean diet, especially the low-sugar, insulin-stabilizing version, has earned well-deserved hype for its positive effects on mood and mental health.

Eat more of: whole grains, vegetables, seafood, olive oil, legumes and low-sugar fruits (raspberries, strawberries, blackberries, and kiwis)

Eat less of: high-sugar fruits and alcohol (and because it can disrupt sleep, consider eliminating red wine and sugary mixed drinks altogether)

As we approach perimenopause and menopause, we’re juggling a lot!

We may be caring for kids or aging parents, busy at work in peak career years, or all of the above. So it’s natural that we’d have a lot on our plates and feel overwhelmed sometimes (or even most of the time). But it’s important to recognize that there are physiological factors at play here as well.

Anxiety, which may (but doesn’t always) go hand-in-hand with depression, is thought to be influenced by fluctuating and declining hormone levels, including:

  • Serotonin: the “happy hormone” that stabilizes our mood and fluctuates with age and decreasing estrogen levels
  • Estrogen: results in increased serotonin levels and increased serotonin receptors. More serotonin = less anxiety and depression. The relationship between these two hormones is complex though and we are just starting to scratch the surface!
  • Progesterone: the “calming hormone” that may also influence GABA
  • Gamma-Aminobutyric acid (GABA): a neurotransmitter that produces a calming effect when it binds to its receptors, which may support a reduction in stress, anxiety, and sleeplessness. With lower progesterone levels, GABA’s receptors don’t bind as well, thereby prolonging the stress response and increasing anxiety.

The most common anxiety symptoms are tension, nervousness, panic, and worry, and some may feel physical signs too, like an upset stomach, headaches, racing heart, sweating, etc. Some women may experience panic attacks, which are an extreme version of anxiety, with the inability to think clearly and accompanied by intense physical symptoms like heart palpitations, shortness of breath, even chest pain.

PMS and PMDD

In early perimenopause, mood fluctuations are typically concentrated in the premenstrual period (PMS) while late perimenopause/early postmenopause is marked by more prominent feelings of general anxiety. The risk of menopause-related depression and anxiety is higher for those with a history of PMDD (premenstrual dysphoric disorder, a more serious form of PMS where symptoms are more intense, which affects 5-7% of menstruating women) and postpartum depression.

Hot flashes and anxiety

There is one interesting connection between hot flashes and anxiety. Research has shown that women who experience anxiety are 3-5x more likely to have hot flashes. Another study found that women who experienced anxiety with physical symptoms (upset stomach, racing heart, etc.) had a strong tendency to have hot flashes.

It’s not clear which comes first: anxiety or hot flashes, but we do know there is a link.

Can the cause of anxiety, mood swings, and depression be independent of menopause? Certainly. That’s why it’s imperative to consult your healthcare provider, especially if you’re experiencing intensive, excessive, and persistent worry or fear about everyday situations that’s difficult to control, interferes with your day-to-day life, and/or peaks within minutes (panic attacks). For help finding a psychologist, we recommend the American Psychological Association’s Locator, as well as the National Register.

What you can do

We’re all about equipping you with the know-how to understand your symptoms, and we especially emphasize the specific, tangible ways to manage them. Our goal is to empower YOU to take charge of your menopause journey, starting today.

Dr. Anna Barbieri, MD

Pro tip #2

New to meditation? Try one of Elektra’s favorite tools: Insight Timer. This app gives you free access to 70,000+ guided meditations, which you can sort by need (anxiety, sleep, etc) and length (1 - 60+ minutes). Be patients with yourself and trust that, over time, you’ll begin seeing results.

Pro tip #3

It may be difficult to know when it’s time to seek out medical advice or support for anxiety. Here are some signs to look out for — although this is in no way a comprehensive list:

• Anxiety is interfering with your job or your relationships, and your sleep

• You’ve tried things to reduce anxiety and nothing is working

• You’re turning to alcohol/drugs as a form of self-medication

• You’re experiencing panic attacks

A quick note about product recommendations…Elektra Health is not paid to feature any products. We just like them and think you might too, though we can’t guarantee any results.

Lifestyle

The effect of lifestyle interventions on mood disorders has been extensively studied, with positive results to show for it. We’re talkin’ everything from meditation to exercise, exposure to nature to improved sleep.

Nutrition & Diet

There is a strong positive correlation between a plant-based Mediterranean diet and a lower risk of anxiety and depression.

The diet is low in saturated fats and animal proteins, rich in antioxidants and fiber, and loaded with B vitamins (which have been clinically proven to impact depression symptoms, anxiety, and stress). It’s anti-inflammatory, veg-heavy, low-carb, low-sugar, and includes brain-healthy fats. And because it kicks most refined and concentrated sugars to the curb and focuses instead on non-starchy veggies, beans, fruits, and whole grains, it’s considered a “low-glycemic index” diet — meaning it won’t dramatically spike our blood sugar. This is what we want!

Holistic Practices

Get out in nature

Routine, frequent exposure to the great outdoors has been shown to reduce anxiety and depression while improving an overall sense of well-being.

Never underestimate the power of Mother Nature (aka vitamin N) to boost your mood!

Reduce stress

This is so, SO important — although easier said than done when everything and everyone seems to be competing for our attention. Here are our top techniques:

  • Cultivate a meditation practice: Over time, you’ll condition yourself to be more present while letting thoughts come and go. We recommend guided meditations on apps such as HeadspaceInsight Timer, and Calm. Meditation not your thing? Try Heartmath, a form of biofeedback that can help with anxiety management. It focuses on breathing and heart rate, two physiologic functions that can contribute to that anxious feeling.

  • Cultivate a gratitude and/or journaling practice: Studies have linked both practices to decreased anxiety, and they can also help improve general feelings of well-being and facilitate mindfulness. 

  • Get high-quality sleep: Sleep disruptions affect neurotransmitter and stress hormone levels which, in turn, impair thinking and emotional regulation. That’s why it’s so important to prioritize those Zzzzsss.

  • Prioritize downtime with family & friends: While we may be conditioned with a “go-go-go” mentality, it’s important to step back and prioritize rest and downtime with loved ones (pencil it into your calendar!). After all, human beings are social creatures, and we derive comfort from connection.

  • Don’t forget about “me” time: Call it what you want — self care, alone time, R&R — but you deserve it. There’s nothing “selfish” about taking time for yourself, especially when it supports your mental health and overall wellness.

Think of “me” time as putting your mask on first in an airplane, so you can be better equipped to help others.

Cognitive Behavioral Therapy (CBT)

CBT involves working with a coach or therapist to recognize and change beliefs — including negative thoughts and worries. That’s the “cognitive” part. And then there’s the “behavioral” part, which helps you develop better habits and mindset. It’s ideal for those looking to address underlying causes of anxiety while working towards long-term management.


Exercise

Scientists have found that regular movement decreases overall levels of tension, elevates and stabilizes your mood, improves sleep, and boosts self-esteem. Not too shabby, right? According to the World Health Organization, 150 minutes per week of moderate intensity movement (a brisk walk counts!) is enough to do the trick and reduce the risk of developing symptoms of anxiety and depression.

Keep things interesting with a mix of different workouts, including strength trainingcardio, and yoga. 150 minutes = about 22 minutes per day — for most of us, that’s very doable!


Supplements & Over-the-Counter Solutions

According to some studies, certain supplements and over-the-counter solutions may help reduce symptoms of anxiety…if you choose wisely. We recommend consulting with your healthcare provider first to ensure you’re using something with optimal efficacy and safety (i.e. backed by clinical research) or consulting with Elektra’s providers.

  • Calm ASAP for Stress Support: Calm ASAP may provide relief from occasional anxiousness with a blend of passionflower, chamomile, vervain, English lavender, and holy basil, all of which have been shown in studies to help with anxiety.

  • Serenol from Bonafide: Serenol is formulated with Swedish flower pollen, an extract made from the pollen and pistils of a certain family of grasses that helps resolve menopausal symptoms (e.g., hot flashes) in addition to emotional effects of PMS.

  • True Calm: True Calm contains a combination of amino acids (GABA, glycine, and taurine) that promote a relaxed, calm state of mind.

  • Metagenics SeroSyn: SeroSyn features L-theanine, an amino acid commonly found in green and black tea leaves that has been studied for its anxiety and stress-reducing properties. It also contains the amino acid 5-HTP, a precursor for serotonin synthesis. It’s important to note any supplements that contain 5-HTP should not be taken with the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) – because it may increase the risk of serotonin syndrome.

Prescription

Hormonal

Before considering hormonal treatments for menopause-related anxiety, it’s critical to consider sleep, nutrition, and stress management — all of which can have a powerful impact on symptoms. If you do opt for hormonal treatments, they should always be coupled with mind-body interventions. In other words, nothing should exist in a silo, especially for something as complex as anxiety.

Data are mixed about whether HRT helps with anxiety, with smaller studies showing conflicting results or no effect. The relationship is clearer between HRT and depression with more data suggesting a positive effect of hormone (particularly estrogen) therapy on depression especially in perimenopause. Given what we know about progesterone influencing GABA receptors, it might be worthwhile to try progesterone supplementation during the 2nd half of your cycle in early perimenopause to help with anxiety that seems to correlate with your menstrual cycle.

It is worthwhile to also mention the option of low-dose birth control, which may be used early in perimenopause for those with PMDD (premenstrual dysphoric disorder, a condition similar to PMS that leads to severe emotional symptoms like anxiety, irritability and/or depression in the week or two prior to your period), or moderate PMS.


Non-Hormonal

SSRIs and SNRIs remain the first line of pharmacologic defense for anxiety and depression in peri- and menopausal women. SSRIs are selective serotonin reuptake inhibitors and SNRIs are serotonin and norepinephrine reuptake inhibitors — total tongue-twisters! These neurotransmitters are antidepressants that work by regulating serotonin (the “happy hormone” that controls mood) and norepinephrine (plays a key role in the body’s “fight-or-flight” response to stress). It should be noted that common side effects include weight gain and low libido.

A note about antidepressants: There is still stigma around taking these medications but for many of us who experience symptoms, they can be incredibly effective and helpful, and we have decades of research to back this up.

Examples of SSRIs are:

  • Escitalopram/Lexapro: associated with less weight gain and sexual side effects (i.e. low libido) than others
  • Venlafaxine/Effexor: associated with higher risk of withdrawal symptoms, so proper weaning is important and should be done under the guidance of your provider



If you’re experiencing an emergency and need immediate help, call 911 or go to the nearest emergency room.

Suicide Prevention Lifeline

+ 1-800-273-8255

Crisis Text Line

Text HOME to 741741


We’re always keeping an eye out on emerging research and the latest clinical studies. Subscribe to our weekly Elektra Digest for the latest, science-based info direct to your inbox. Something work well for you that’s not listed here? We want to hear it! Shoot us a note at [email protected]. (We’re human, promise.)

Disclaimer: This information is for general educational purposes, and should not be used as a substitute for medical advice, diagnosis, or treatment of any health condition or problem.

As with anything you put into your body, taking dietary supplements can also involve health risks. You should consult a medical professional before taking supplements and inform your doctor about any supplements, as well as any medications you already take, since there may be interactions.

References

Last reviewed 8/30/21

Bromberger, J. T., Kravitz, H. M., Chang, Y., Randolph, J. F., Avis, N. E., Gold, E. B., & Matthews, K. A. (2013). Does risk for anxiety increase during the menopausal transition? Study of Women’s Health Across the Nation. Menopause: The Journal of The North American Menopause Society, 1.

Beck, T. (2012, August 9). Estrogen and female anxiety. Harvard Gazette.

Yasgur, B. S. (2018, December 17). Mood Changes in Menopausal Women: A Focus on Anxiety. Psychiatry Advisor.

Anxiety disorders - Symptoms and causes.(2018, May 4). Mayo Clinic.

Ventriglio, A., Sancassiani, F., Contu, M. P., Latorre, M., Di Slavatore, M., Fornaro, M., & Bhugra, D. (2020). Mediterranean Diet and its Benefits on Health and Mental Health: A Literature Review. Clinical Practice & Epidemiology in Mental Health, 16(1), 156–164.

Gunnars, K. B. (2018, July 24). Mediterranean Diet 101: A Meal Plan and Beginner’s Guide. Healthline.

Young, L. M., Pipingas, A., White, D. J., Gauci, S., & Scholey, A. (2019). A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals. Nutrients, 11(9), 2232.Harvard Health Publishing. (2014, February). 8 principles of low-glycemic eating. Harvard Health.

Spend Time in Nature to Reduce Stress and Anxiety. (n.d.). Www.Heart.Org.

Harvard Health Publishing. (2011b, November). Giving thanks can make you happier. Harvard Health.

Cohut, M. (2018, February 23). What are the health benefits of being social? Medical News Today.

Exercise for Stress and Anxiety | Anxiety and Depression Association of America, ADAA. (n.d.). Anxiety And Depression Association Of America.

Siefken, K., Junge, A., & Laemmle, L. (2019). How does sport affect mental health? An investigation into the relationship of leisure-time physical activity with depression and anxiety. Human Movement, 20(1), 62–74.

Passionflower. (2020, February 24). Memorial Sloan Kettering Cancer Center.

Unilever Food and Health Research Institute, Vlaardingen, The Netherlands, Department of Experimental Psychology, Oxford University, UK, Novre, A. C., Rao, A., & Owen, G. N. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr.

Villines, Z. (2020, October 23). What are the differences between SSRIs and SNRIs? Medical News Today.

Ackerman, C. M. E. (2020, October 12). 83 Benefits of Journaling for Depression, Anxiety, and Stress. PositivePsychology.Com.

Chowdhury, R. B. M. A. (2020, September 1). The Neuroscience of Gratitude and How It Affects Anxiety & Grief. PositivePsychology.Com.

Ortmann, O., Beckermann, M. J., Inwald, E. C., Strowitzki, T., Windler, E., & Tempfer, C. (2020). Peri- and postmenopause—diagnosis and interventions interdisciplinary S3 guideline of the association of the scientific medical societies in Germany (AWMF 015/062): short version. Archives of Gynecology and Obstetrics, 302(3), 763–777.


Let us know what you think!